Synthesis and characterization of styrene – maleic anhydride copolymer derivatives

[摘要] ENGLISH ABSTRACT:In this study, a functional styrene – maleic anhydride copolymer (SMA) was synthesized viareversible addition-fragmentation chain transfer mediated polymerization (RAFT). Theobtained copolymer had an alternating structure with well controlled molecular weight. Thestructure of the copolymer was found to alternating when characterized by NMR andMALDI-Tof-MS.SMA copolymer is functional polymer due to the presence of reactive maleic anhydridemoiety in its backbone. The SMA copolymer was used as a starting material for synthesis ofother three copolymers with potential anti-viral activity. These three copolymers are referredto as SMA copolymer derivatives because they were synthesized by reacting either maleicanhydride or styrene moieties with certain chemical compounds. The three derivedcopolymers are; styrene-maleimde copolymer (SMI), styrene sulfonate-maleic anhydridecopolymer (SSMA) and styrene sulfonate– maleimide copolymer (SSMI).SMI was synthesized by reacting 4-aminomethylbenzene sulfonamide compound withmaleic anhydride moieties on the backbone of SMA copolymer. The reaction proceeded inthe presence of co-catalysts triethylamine and dimethylamino pyridine to from amidelinkages. The copolymer was characterized by NMR spectroscopy, SEC and FTIRspectroscopy.SSMA copolymer was successfully synthesized by reacting styrene moieties of the SMAcopolymers with chlorosulfonic acid. The SSMA copolymer was further reacted with aminecompound to synthesize SSMI copolymer. The synthesis of SSMI was achieved by reactingthe maleic anhydride moieties in the backbone of the SSMA copolymer with N1,N1-dimethylpropane-1,3-diamine. Both copolymers were successfully characterized by FTIRspectroscopy.

[发布机构] Stellenbosch University