Algorithm to calculate proportion of genes identity by descent, to map QTL in half-sibs families

[摘要] - The development of linkage maps has stimulated the search for methods to map genes involved with quantitative trait loci (QTL). A sib par method based on the relation between individuals identic by descent (IBD) has been used to map QTLs. The objective of this paper was to extend the HASEMAN and ELSTON (1972) method to estimate the proportion (p) of genes IBD in half-sib families. The obtained results suggested that the used procedures were efficient to estimate p even when parents genotypes were partial or totally unknown.

[学科分类] 兽医学

[关键词] genes identity by descent;half-sibs;QTL     IntroduçãoO desenvolvimento de mapas de ligação com grande número de marcadores moleculares tem estimulado a procura por métodos que permitam mapear genes responsáveis por variação em características quantitativas