The effects ofthe ionophore (sodic monensin) and of the probiotic (Saccharomyces cerevisiae+ selenium + chrome) were evaluated in rations with 50:50% of forage:concentrateratio on the total (TDC) and partial [ruminal digestibility coefficients(RDC) and intestinal (IDN)] nutrients digestibility coefficients. ThreeMurrah buffalos (Bubalus bubalis) and three steers Holstein (Bos taurus),with an of 477 ± 47 kg and 518 ± 56 kg of average weight respectively,and with ruminal and duodenal cannulas were used; the animals were designedinto two 3 ´ 3 latin squares and in a 3 ´2 factorial arrangement. The acid insoluble ash was the internal marker forfecal and duodenal flow. No interaction of diet and animal species for TDC ofnutrients was observed, although the ionophore addition in the ration showeda positive effect on TDC for DM, CP, EE and starch and the probiotic additionincreased TDC of starch, NDF and ADF. The ionophore and probiotic addition providedhigher ruminal fermentation of NDF and ADF and higher IDC of starch. It wasobserved higher TDC of CP and starch for bovine and higher TDC of NDF for buffaloes.There was interaction of rations ´ speciesonly on RDC and IDC for DM, CP and EE. The ionophore addition was effectiveto increase the ruminal fermentation of DM, to reduce ruminal degradation ofCP and to increase IDC of CP for both species. The probiotic addition also reducesruminal degradation of CP in buffaloes, but in lower scale than ionophore. Forbuffaloes, the presence or absence of additives in rations caused higher RDCof DM, the absence of addictives in ration caused higher RDC and lower IDC ofCP than in bovine.