Correlates of self-reported dietary cruciferous vegetable intake and urinary isothiocyanate from two cohorts in China

[摘要] AbstractObjectiveTo assess correlations between cruciferous vegetable intake and urinary isothiocyanate (ITC) level, in addition to glutathione S-transferase (GST) genotypes and other individual factors.DesignThe study included cohort participants whose urinary ITC levels had been previously ascertained. Urinary ITC was assessed using HPLC. Usual dietary intake of cruciferous vegetables was assessed using a validated FFQ and total dietary ITC intake was calculated. Recent cruciferous vegetable intake was determined. GST genotypes were assessed using duplex real-time quantitative PCR assays. Spearman correlations were calculated between the covariates and urinary ITC levels and linear regression analyses were used to calculate the mean urinary ITC excretion according to GST genotype.SettingUrban city in China.SubjectsThe study included 3589 women and 1015 men from the Shanghai Women’s and Men’s Health Studies.ResultsMedian urinary ITC level was 1·61 nmol/mg creatinine. Self-reported usual cruciferous vegetable intake was weakly correlated with urinary ITC level (rs=0·1149; P

[学科分类] 卫生学

[关键词] Brassicaceae;China;Glutathione S-transferase M1;Glutathione S-transferase T1