Effects of a dairy product fortified with multiple micronutrients andomega-3 fatty acids on birth weight and gestation duration in pregnant Chileanwomen

[摘要] ObjectiveTo test the hypothesis that maternal food fortification with omega-3 fattyacids and multiple micronutrients increases birth weight and gestationduration, as primary outcomes.DesignNon-blinded, randomised controlled study.SettingPregnant women received powdered milk during their health check-ups at 19antenatal clinics and delivered at two maternity hospitals in Santiago,Chile.SubjectPregnant women were assigned to receive regular powdered milk (n = 477) or a milk product fortified withmultiple micronutrients and omega-3 fatty acids (n = 495).ResultsIntention-to-treat analysis showed that mean birth weight was higher in theintervention group than in controls (65.4 g difference, 95% confidenceinterval (CI) 5–126 g; P =0.03) and the incidence of very preterm birth (0.80 just for mean birth weight and birth length in theon-treatment analysis; birth length in that analysis had a difference of0.57 cm (95% CI 0.19–0.96 cm; P = 0.003).ConclusionsThe new intervention resulted in increased mean birth weight. Associationswith gestation duration and most secondary outcomes need a larger samplesize for confirmation.

[学科分类] 卫生学

[关键词] Maternal nutrition;Food supplementation;Multiple micronutrients;Omega-3 fatty acids;Birth weight;Gestation duration