Histological alterations caused by Venezuelan chewing tobacco (Chim贸) present in periodontal tissues in rats

[摘要] Chimó is a tobacco derivative used in Venezuela containing nicotine. Its harmlessness has been questionated due to potential damages on periodontal tissues. Aim of present research was to study histological alterations that chimó could causes on periodontal tissues in Wistar rats. Twelve male Wistar rats were selected, 12 were the control group and 12 the experimental one. Control group received physiologic solution and the experimental one received chimó in a dosage of 18g/5cc (chimó/physiologic solution) to both groups by topical via (rubbing). Application frequency: three days/week during 20 weeks. In control group there was not changes. Experimental group showed Orthokeratosis (54 %), slight epithelial dysplasia (45 %), granulocytes, hyperkeratosis, acanthosis, fibrosis, and stroma collagen disease and chronic inflammation (19 %), and a moderate dysplasia (10 %). We conclude that histological changes seen are directly related to chimó exposure time.

[学科分类] 基础医学

[关键词] /I> Effects/gingival;tobacco/chew;chimó/ nicotine