Congenital malformations are defined as geneticallydetermined structural defects present in the child at birth. Thousand congenitaldefects have been identified. Lip-palate fissures are congenital structuraldeficiencies due to a faulty fusion of some developing embryonal facial process.This defect is usually found in live-born children. In present study we intendedto identify behavior of lip, palate fissures, or both in sick mother duringpregnancy. Thus, we analyzed all the live-born children diagnosed with lip,palate fissure, or both during 2000-2006 years in Havana City province, witha study sample of 112 patients. Form was designed to get the information relatedto diseases present in the patient's mothers during pregnancy. Most of motherswhose children had fissures had diseases during pregnancy. The trimester ofgreat affection was the third one, and the most frequent disease was the highblood pressure.