抗アレルギー剤；Suplatast Tosilate のリードジェネレーション

[摘要] References(17)Cited-By(3)The reaction of transmethylation plays an important role in the immune system. Some kinds of sulfonium compounds, which have a labile methyl group, are considered to become the supply source for methyl groups in biological systems. We examined the physicochemical properties of sulfonium compounds from the point of structure activity relationships analysis in order to develop an antiallergy drug. We found that several sulfonium compounds have immunological activity, and 2-hydroxyethyldimethylsulfonium p-toluenesulfonate (4) was chosen as the lead compound for further studies.

[学科分类] 生物化学/生物物理

[关键词] Suplatast Tosialate;Sulfonium Compound;Antiallergy Drug;Ion Pairs;Transport Rate;Suplatast Tosilate;Sulfonium Compound;Antiallergy Drug;Ion Pairs;Transport Rate