酵母DNAマイクロアレイを用いた�?�重金属で誘導される遺伝子発現の比較

[摘要] References(5)Cited-By(10)cDNA microarrays are very convenient tools that can be used to understand changes in genome-wide patterns of gene expression. The yeast DNA microarray contains 5880 ORF cDNA probes, which is almost whole genome, on a glass slide. We analyzed genome-wide transcript profiles following exposure to Cadmium (Cd) or Mercury (Hg) with the yeast DNA microarray, and while 22 genes were induced by both heavy metals, there were many discrepancies in those profiles. From these results, we concluded that yeast microarrays are valuable for bioassay of environmental agents.

[学科分类] 生物化学/生物物理

[关键词] microarray;yeast;heavy metals;Cd;Hg;マイクロアレイ;酵母;重金属;カドミウム;水銀