Bezoarsare masses composed of foreign material, partially digested or not, found in anyportion of the gastrointestinal tract. Rarely bezoars are composed by medicationtablets, becoming known as Pharmacobezoars. This article reports a patient withthe Crohn's disease complicated by enteric fistulae and stenotic areas in theileum presenting Mesalazine pharmacobezoars. The author emphasizes the multi-factorialorigin of pharmacobezoars, the wide range of clinical presentations and the diagnostictools useful in these cases. The individualized treatment necessary to obtainthe satisfactory clinical results is also highlighted.