Purpose:To investigate the association of overweight and abdominal fat with CRC/Ad. Methods:From January 2007 to December 2008, 1287 patients over 50 years of age, withoutknown risk factors for CRC/Ad (455 men and 832 women), were submitted to a completecolonoscopy and had the BMI and WHR calculated. Student t-test was used for statisticalanalysis of means and chi-square to compare absolute numbers. A significant P-valuewas defined as < 0,05. Results: Neoplastic lesions were found in 542 (42,1%)subjects, being 231 (50,7%) male and 311 (37,3%) female. BMI > 30 ledto 43 (18,6%) CRC/Ad male and 84 (27%) female P> 0,05 Patients with BMI <30 were found to have CRC/Ad 188 (49,4%) male and 227 (36%) female P> 0,05.WHR was 0,96±0,05 cm for male with tumor and 0,94±0,07 without tumorP< 0,01. For female WHR was 0,89±0,06 with tumor and 0,88±0,06 withouttumor P< 0,05. Conclusions: These findings suggests that BMI was not associatedwith CRC/Ad but WHR could be a predictor for an increased risk of colon neoplasia.