Venous thromboembolic disease is a common cause of mortality and morbidity in patients with cancer. Patients have a 5-6 fold increase in the risk for a venous thromboembolism compared with the general population. Colorectal surgery in these patients implies a specific high risk for postoperative thromboembolic complications. This article reports a case of a 46 years old patient with colorectal cancer and peritoneal carcinomatosis developing thromboembolic complications, and literature review.