The relation between metastases in regional lymph nodes and prognostic factors in the sporadic adenocarcinoma of the large bowel

[摘要] INTRODUCTION: The colorretal carcinoma corresponds to the one of the most frequent malignant neoplasias in Brazil, being the third cause of death for malignant tumors in women and fifth in men. Certain histopathological characteristics of the tumor, as so grade, size and presence of metastases, can be correlated with free long term of disease.OBJECTIVE: to evaluate the association between metastases in lymph nodes and histopathological data in the colorretal adenocarcinoma.METHOD: There were evaluated 50 specimens of colectomy for adenocarcinoma between 2006 and 2008, being studied the following data: topography, tumoral size, macroscopic configuration, histological grade, depth of invasion, microscopical edge, presence of metastases in lymph nodes and staging (TNM, Dukes and Astler-Coller systems).RESULTS: the median age was 63,7 years-old, predominantly in women (n=26-52%) and in the left colon/rectum (n=29-58%). There weren´t association between the presence of metastatic lymph nodes with regard to age (p=0,802), sex (p=0,786), microscopic borders (p=0,180), presence of mucinous areas (p=0,860), grade (p=0,068), and size (p=0,987).CONCLUSION: In the colorretal adenocarcinoma, the presence of nodal metastases is not associated to the size, microscopic borders and grade, been necessary the evaluation of new factors, possibly molecular events, to predict the presence of nodal metastasis.

[学科分类] 心脏病和心血管学

[关键词] Adenocarcinoma;colon;lymph nodes;pathology