AlthoughCrohn's disease (CD) is associated with an increased risk for developing cancer,there are less than 150 cases reported in the world literature. Main risk factorsinclude early onset, a long period of disease, chronic fistulous disease andexcluded bowel presence. Case report. MCAN, 53 years old, female, white, hasbeen submitted to a right ileocolectomy at the age of 17, due to bowel obstructioncaused by distal ileum CD. A year ago, she presented a new obstructive episodeand at laparotomy a tumor mass was identified in the ileocolic anastomosis.Pathology confirmed a mucinous adenocarcinoma. Discussion. The majority of patientswith CD who develop intestinal cancer have in common the following items: cancerinstalls many years after the first symptoms, in around 80% of the cases after20 years of the CD diagnosis; bowel obstruction is the main problem; lesionsare very aggressive, and only 10% of the patients remain two years free of thedisease.