The great partof the morbimortality associated with the colorretal surgery, is related withthe anastomotic dehiscence. Experimental trials on the utility of tissue adhesivesin the colonic anastomosis are controversial, as well as prospective randomizedclinical studies are absent. BioGlue® Surgical Adhesive(BSA) is a two-componentsurgical adhesive composed of purified bovine serum albumin and glutaraldehyde.The glutaraldehyde molecules covalently bond (cross-link) the BSA moleculesto each other and, upon application, to the tissue proteins at the repair site.The aim of this study is to evaluate the effectiveness of the BioGlue® inthe prevention of the anastomotic colonic dehiscence in rats. Thirty male Wistarrats had been used. The colocolonic anastomosis was confectioned with separatestitches with polypropylene 5-0 (group 1) and the application of the BioGlue®Surgical Adhesive (group 2). The formation and extension of the adhesions, thehistological alterations and the rupture pressure had been evaluated. In thegroup 1, we have only 7% of mortality (01 animal), being evidenced in the autopsy,intestinal obstruction with major bowel distension. The mortality in group 2,on the other hand, was 67% (10 animals), being observed: bowel distension, anastomoticdehiscence and, in some situations, fecal peritonitis because of anastomotictotal dehiscence. We concluded in the present study that, the use of BioGlue®Surgical Adhesive in colonic anastomosis in rats, is associated with an increaseof the morbimortality in comparison with conventional suture which was statisticallysignificant.
