In the treatmentof the anal fissure, calcium channel blockers are among the new drugs whichhave been used. The objective of this research was the manometric evaluationof patients with chronic anal fissure after topic treatment with 0.2% nifedipineand correlation with the healing and pain. This is a prospective study of patientsfrom Coloproctology Clinic of the University of Taubaté Hospital. Thepatients had been submitted to a manometric examination before and after 30days of the use of topic 0.2% nifedipine gel three times a day in the anus andanal edge. For the statistics analysis Mann-Whitney test was applied to a significanceof p= 0,05. Ten patients did not exihibit manometric alteration associated withnifedipina treatment, however 50% of them reported improvement of the symptomsand 40% depicted healing of the fissure. The results demonstrated that nifedipinewas effective and safe for anal fissure treatment and considering the functionalpoint of view it did not cause injuries as well. The manometric evaluation didnot demonstrate alterations in the anal pressure; however, it was observed that50% of the patients had improvement in pain and 40% in healing.
