Development of a technology for obtaining the Momordica charantia L. aqueous extract

[摘要] Introduction: Momordica charantia L. aqueous extracts have scientifically-confirmed therapeutical potential, which makes it possible to use it in the treatment of several diseases, particulary diabetes. Obtaining a standardized extract is of great importance to reproduce it at industrial scale and also to obtain a pharmaceutically active ingredient (FAI) for the development of orally administered finished forms. Objectives: to develop a technology at lab scale to obtain standardized aqueous extract from Momordica charantia L. Methods: the study of the operational parameters (vegetal matter-solvent ration and extraction time) was performed in a lab reactor designed according to the dimensions of an industrial reactor, with a 3-level surface design of factorial response (3^2). Results: the studied factors significantly influence the extraction process in which time is the most influential. There exists direct proportion between vegetal matter-solvent ration and the content of extracted solids, being the latter inversely proportionate to the extraction time. The highest content of extracted solids was reached with vegetal matter-solvent ratio of 1:25 and extraction time of 0.5 hours. Conclusions: the operational conditions that support the highest solid extraction in obtaining the aqueous extract at the experimental phase were determined when the vegetal matter-solvent ratio and the extraction time were 1:25 and 0.5 hours respectively.

[学科分类] 药理学

[关键词] extracto acuoso;extracto estandarizado;Momordica charantia L