Phytochemical prospection and antiplasmoidal activity of the hexane extract from Montrichardia linifera (Arruda) Schott

[摘要] Introduction: Montrichardia linifera extracts showed high toxicity to Artemia salina, which indicated high biological potential for antitumoral, antibacterial, antifungal activities, and action against Trypanossoma cruzi. Objective: to evaluate the antimalarial potential of the hexane extract from the Montrichardia linifera (Arruda) Schott leaves and to discover its phytochemical profile. Methods: the phytochemical prospection was conducted by the precipitation method whereas the antiplasmodial activity was evaluated in vitro using the W2 Plasmodium falciparum clone. Results: the phytochemical prospection just suggested the presence of steroids. Regarding the antiplasmodial activity after 24 hours at 100 µg/mL concentration, the parasite growth inhibition was 50.5 % but at other concentration ranges, significant inhibition was not observed. At 48 hours, the growth inhibition at 100 µg/mL concentrations was 34.7 %. After 72 hours, hemolysis was observed at 100 µg/mL and 50 µg/mL concentrations, so the percentage determination of the parasites was not possible. Conclusions: the hexane extract obtained from the M. linifera leaves presented with low antimalarial potential and proved to be positive for steroids.

[学科分类] 药理学

[关键词] Montrichardia linifera;Plasmodium falciparum and steroids