Acute oral toxicity of Solanum torvum Sw. (prendejera)

[摘要] Introduction: Solanum torvum Sw., traditionally known as prendejera, is a medicinal plant used by the population as antimicrobial and anti-inflammatory agent among other properties. No acute toxicity studies are reported on this plant, just long-term toxicity studies.Objectives: to evaluate the acute oral toxicity by the class method using decoction of Solanum torvum leaves and stems orally administered to Sprague Dawley rats. Methods: an acute oral toxicity test based on the class method was conducted. The S.torvum plant decoction was administered in one dose of 2000 mg/kg of body weight. Pathological anatomy studies were performed to analyze the toxicity in the tested substance. Results: the evaluated substance did not show any clinical signs of toxicity or animal deaths; no alterations in the body weight of the experimental models were found. There were no alterations of diagnostic value according to the macroscopic analysis. Conclusions: the tested decoction, orally administered at one dose, is regarded as unclassified for the animal model and the dosage used under the observed experimental conditions.

[学科分类] 药理学

[关键词] : medicinal plants;acute toxicity;toxicity test;Solanum torvum