Efecto de Spirulina platensis en la neuropat铆a axonal inducida por acrilamida en ratones

[摘要] INTRODUCTION: Spirulina platensis is a green-blue microalga of a high nutritional value, which has been used as dietary supplement. Some of its constituents help in maintenance of structure and function of nerve tissues. OBJECTIVE: to determine the effect of this microalga on a model of acrylamide-induced axonal neuropathy in mice.METHODS: model included daily administration of 70 mg/kg of acrylamide (subcutaneous route) during 3 consecutive weeks; with estimation of neurotoxic effect of this compound by means of registry, in leg muscles, of composed muscular action potential, during supramaximal stimulation of sciatic nerve. After injections of acrylamide, S. platensis was administered per os, in doses of 400 mg/kg during 5 weeks.RESULTS: at the end of acrylamide administration animals showed a significance decrease of potentials, accompanied by the motor signs of neuropathy. Administration of S. platensis shortens recovery period, evidenced by a quicker restoration of potential values, as well as by a progressive decrease of affected animals' ratio.CONCLUSIONS: findings showed a beneficial effect of S. platensis on acrylamide-induced axonal neuropathy.

[学科分类] 药理学

[关键词] : acrylamide;sciatic nerve;axonal neuropathy;neuroregeneration;Spirulina platensis