Actividad antimicrobiana e irritabilidad vaginal y d茅rmica de extractos acuosos de hojas secas de Solanum americanum Mill.

[摘要] INTRODUCTION: Solanum americanum Mill (yerba mora) is used in a traditional way to treat skin ulcers, it is used also as antiinflammatory and antiseptic in skin diseases and in cervicovaginitis. However, there are few preclinical studies validating it.OBJECTIVE: To assess antimicrobial activity, vaginal and skin irritability of 2 decoctions of dry leaves of Solanum americanun Mill.METHODS: Two aqueous extracts were prepared from: a) dry leaves to 20% and antimicrobial activity was assessed by means of diffusion method in agar, versus microorganisms Candida albicans, Escherichia coli, Klebsiella pneumonia, and Salmonella thyphymurium; as well as irritability in rabbit vagina by Draize method. b) dry leaves to 30%, and skin irritability by Draize method in rabbits.RESULTS: Using a decoction of dry leaves to 20%, we achieved a growing inhibition halo of 15.5 mm with Candida albicans; but not inhibition using other study drugs; there was a minimal vaginal irritability and not erythema and edema in skin of animals using a decoction of dry leaves to 30%.CONCLUSIONS: Decoction of dry leaves of S. americanum showed antimicrobial activity versus C. albicans but not against other microorganism, with a minimal vaginal irritability, and was classified as non-irritant in skin; consequently, they may be used in affections provoked by C. albicans in skin and in vagina.

[学科分类] 药理学

[关键词] : Solanum americanum;antimicrobial;skin irritability;vaginal irritability