Subchronic toxicology of the aqueous extract of Plectranthus amboinicus (Lour.) Spreng

[摘要] OBJECTIVES: Due to the wide use of Plectranthus amboinicus (Lour.) Spreng. (French oregano) in the population and to its possible use on the long term in the convulsive affections and the respiratory tract, it was recommended the toxicological subchronic study of an aqueous extract (freeze-dried) of the aerial parts. METHODS: the study was conducted in Wistar rats of both sexes. Doses of 500 and 50 mg of freeze-dried total solids/kg of body weight were administered by oral route during 90 days. The animals were weekly weighted and at the end of the treatment they were sampled to determine the haematological and blood chemical indicators, as well as the histological study of organs. RESULTS: the behavior of the animals and the evaluated indicators were not affected by the treatment. The microscopic alterations observed in the animals were sporadic with a very low incidence in all groups. CONCLUSIONS: the study did not prove the existence of toxic effects in the animals that could be associated with the repeated administration of the freeze-dried aqueous extract of Plectranthus amboinicus.

[学科分类] 药理学

[关键词] : Wistar rats;Plectranthus amboinicus;subchronic toxicity;French oregano;aqueous extract