Toxicological study of an aqueous extract from Enterolobium cyclocarpum (Jacq.) Griseb. duramen

[摘要] Rationale: A protective effect of the aqueous extract from Enterolobium cyclocarpum (Jacq.) Griseb duramen on pinewood was reported. It was also attributed anti-nutritional and repellent action against dry wood termites Incisitermes marginipennis (Latreillé); it is considered a potential candidate for perishable dry wood preservation, whose possible toxicity must be studied.Objectives: To determine the toxicity of aqueous extract from E. cyclocarpum duramen.Methods: Mean inhibitory and lethal concentrations (IC50/LC50) of an aqueous extract from E. cyclocarpum duramen in organisms from different trophic levels.Results: LC50 for Artemia salina crustacean, I. marginipennis termite and Wistar rat were 1,3; 2 mg/mL and over 2 000 mg/kgind respectively. In microbial isolates, IC50 was 300 mg. In MCF-7 tumor cell line, IC50 was 1,3 mg.Conclusions: When comparing observed IC50/LC50 with allowable toxicity limits, it was concluded that the extract under study was not toxic for these organisms.

[学科分类] 药理学

[关键词] : IC50/LC50;crustacean;termite;rat;bacteria;fungus;oomicet;MCF-7 cells