Adrenergic Overstimulation: A Neglected Mechanism of Sepsis-Related Cardiomyopathy

[摘要] We read with great interest the paper by Martin et al¹ about septic cardiomyopathy in a recent issue of CHEST (February 2019). In particular, we were impressed by the examination of the etiopathologic mechanisms of sepsis-related cardiomyopathy. However, we think the effect produced by adrenergic stimulation in determining cardiac dysfunction in patients with sepsis has not been addressed. Continuous adrenergic overstimulation constitutes, in the stage immediately after the initial compensation phase, an activation of beta-1 receptors.

[学科分类] 呼吸医学