The hydrology of malaria : field observations and mechanistic modeling of the malaria transmission response to environmental climatic variability

[摘要] (cont.) The results are consistent with various paradoxical observations in the literature of unexpectedly low prevalence with higher biting pressure. HYDREMATS represents acquired immunity as dependent on repeated inoculations of malaria, with a slow loss of immunity in the absence of infectious bites. Because climate variability determines variability in vectorial capacity, in an endemic environment acquired immunity level in a human population has a memory of past climate variability. Model experiments in Banizoumbou evaluating the impacts of climate shifts confirm this.

[发布机构] Massachusetts Institute of Technology