Role of cutaneous T-cell-attracting chemokine and interleukin-32 in the pathogenesis of mycosis fungoides

[摘要] Background Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Interleukin (IL)-32 is a proinflammatory cytokine expressed by activated natural killer cells, T cells, keratinocytes, and fibroblasts. Cutaneous T-cell-attracting chemokine (CTACK/CCL27) is selectively expressed in the skin and attracts CC chemokine receptor 10-expressing skin-homing memory T cells. Objective To investigate the role of IL-32 and CTACK in the pathogenesis of MF by assessing IL-32 and CTACK levels in patients with MF and normal controls. Patients and methods Serum samples and skin biopsies from lesional and nonlesional skin of 16 patients and controls were collected to examine CTACK and IL-32 levels using ELISA, and results were compared with controls. In six patients, we collected the sera before and after treatment. Results A highly significant difference between cases and controls regarding CTACK and IL-32 serum and tissue levels was found in this case–control study. A highly significant difference between CTACK and IL-32 levels in lesional tissue, nonlesional tissue, and normal skin was found. IL-32 and CTACK markers were strongly correlated with the types of skin lesions. In six patients, serum CTACK and IL-32 were significantly decreased after treatment. Conclusion CTACK/CC chemokine receptor 27 and IL-32 may play an important role in the pathophysiology of MF.

[学科分类] 皮肤病学