0113 The Gut Microbial Correlates of Strain-Specific Sleep Fragmentation in A Spaceflight Analog

[摘要] IntroductionThe mammalian gastrointestinal microbiota interacts with the functions of the central nervous system, including sleep. Spaceflight is associated with disrupted sleep in astronauts, and our previous work has found altered gut microbiota during spaceflight in both humans and mice. To understand the role of the gut microbiota in disrupted sleep and the associated physiological changes under simulated spaceflight-like conditions, we studied mice in a spaceflight analog, hindlimb unloading (HLU), which models a non-load-bearing status in the hindlimbs, cephalic fluid shifts, as well as situational and confinement stress.

[学科分类] 生理学