0124 Brain Resident Mast Cells Regulate Brain Histamine Content and Promote Wakefulness

[摘要] IntroductionMast cells release various chemical mediators such as histamine and cytokines and play a central role in acute allergic reaction in peripheral organs. Recent studies showed some contributions of brain resident mast cells to brain histamine content and neurological functions. Our previous study demonstrated that wake-promoting effect by a histamine releaser was abolished in congenital mast cell deficient W/Wv mice (i.e., c-kit mutant mice). However, it is known that the mutant mice have multiple organ abnormalities beside mast cell deficiency. Here, we examined the roles of brain-resident mast cells in sleep/wake regulations using inducible mast cell and basophil deficient mice.

[学科分类] 生理学