0008 Impaired Post Illumination Pupil Response in Individuals with Delayed Sleep Wake Phase Disorder

[摘要] IntroductionDelayed sleep wake phase disorder (DSWPD) is characterized by a delayed sleep/wake cycle with respect to the external environment. Although it is the most commonly diagnosed circadian rhythm sleep wake disorder, its pathophysiology remains unclear. We tested the hypothesis that individuals with DSWPD have impaired phototransduction of their melanopsin containing intrinsically photosensitive retinal ganglion cells (ipRGCs) as measured by the post illumination pupil response (PIPR).

[学科分类] 生理学