0002 Leptin Receptor Positive Neurons In The Dorsomedial Hypothalamus Maintain Upper Airway Patency During Sleep

[摘要] IntroductionBoth deficiency of adipocyte-produced hormone leptin and resistance to leptin’s effects cause obstructive sleep apnea (OSA) and obesity hypoventilation syndrome (OHS), which are reversed by leptin delivery to the brain. However, mechanisms of leptin’s effect on sleep disordered breathing remain unknown. We previously shown a retrograde neuronal tracer pseudorabies virus injected in the genioglossus muscle of the tongue spreads to the dorsomedial hypothalamus (DMH), which abundantly expresses leptin receptor LepRb. We hypothesized that LepRb+ neurons in DMH project to the hypoglossal motoneurons and upon excitation with leptin activate these neurons to prevent OSA.

[学科分类] 生理学