0019 Identifying The Targets Of Estradiol In HUVECs Exposed To Intermittent Hypoxia: The Possible Involvement Of ATM-cIAP Pathway

[摘要] IntroductionChronic intermittent hypoxia (CIH) contributes to the increased risk of cardiovascular diseases in obstructive sleep apnea (OSA) through inducing oxidative stress and increasing endothelial cell apoptosis. We previously reported anti-oxidant and anti-apoptotic effects of estradiol (E2) on IH-exposed human umbilical vein endothelial cells (HUVECs). In this study, we employed a proteomic analysis to elucidate the molecular mechanisms of protective effects of estradiol under IH exposure.

[学科分类] 生理学