0061 Sleep Duration And Timing In Relationship to Toxoplasma Gondii Igg Serointensity In The Old Order Amish

[摘要] IntroductionDisruption of sleep is associated with mental illness and suicidal behavior. Toxoplasma gondii (T. gondii), a neurotropic parasite has been linked with schizophrenia, mood disorders and suicidal behavior, and is able to synthetize dopamine and to elicit immune activation factors that may contribute to changes in sleep duration and timing. Our group proposed that sleep disruption could mediate in part a possible link between the parasite and mental illness. We previously found no associations between markers of T. gondii infection and sleep but did not account for relatedness within the Amish. We hypothesized that serointensity and seropositivity of T. gondii will be associated with shorter sleep duration and delayed sleep in the Old Order Amish- a group with less lifestyle heterogeneity, no home exposure to network electric light and much lower rates of substance abuse in adults than in other populations.

[学科分类] 生理学