0059 3-D Reconstruction of Neurons Driving Circadian Rhythms

[摘要] IntroductionMammalian circadian rhythms are regulated by a master circadian clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus. SCN neurons display self-sustained oscillations that are maintained by a molecular transcriptional-translational feedback loop. Communicative processes between SCN neurons synchronize noisy oscillations at the single neuron level to generate coherent output rhythms at the tissue level that display selective robustness and plasticity to entrain the SCN and peripheral clocks throughout the brain and body. The aim of this study was to digitally reconstruct mouse SCN neurons using serial electron microscopy techniques to describe the synaptic and non-synaptic intercellular mechanisms between SCN neurons.

[学科分类] 生理学