0093 Orexin Receptor Antagonism Improves Stress-related Insomnia, “Next Day” Hypersomnia, And Sleep Dependent Memory Consolidation In The Rat

[摘要] IntroductionSleep facilitates learning and memory, and sleep loss/disruption such as experienced in insomnia may impact cognition. Of utmost importance is the development of hypnotics that improve the sleep profile of the insomniac, but minimally impair sleep dependent memory consolidation (SDMC) and “next day” cognition. Here, we evaluated if treatment in the rat with the dual orexin receptor antagonist DORA-22 (Merck & Co., Inc.) would improve insomnia-related sleep disruption, consequent hypersomnia, as well as memory impairment.

[学科分类] 生理学