0073 Activation of Leptin Receptor Positive Neurons in the Nucleus of The Solitary Tract (NTS) Alleviates Sleep Disordered Breathing in Obese Mice

[摘要] IntroductionObstructive Sleep Apnea (OSA) is a major cause of morbidity and mortality with high prevalence. The loss of motor input related to deeper sleep stages lead to recurrent pharyngeal collapse (apneas and hypopneas), leading to oxyhemoglobin desaturations and arousals. There is still no effective pharmacotherapy for OSA. Leptin is a powerful respiratory stimulant and long isoform of leptin receptor, LepRb in the brain is an important therapeutic target in sleep disordered breathing.

[学科分类] 生理学