0125 Dexmedetomidine Causes Age-Dependent Differences in the EEG Compared to NREM Sleep in B6 Mice

[摘要] IntroductionDexmedetomidine (dex) is an alpha 2A adrenergic receptor agonist that is used clinically as a sedative. Dex is thought to induce sedation via disinhibition of the preoptic area which is similar to what occurs during non-rapid eye movement (NREM) sleep induction. Human, cat and rat electroencephalogram (EEG) studies have shown similarities between NREM sleep and dex induced sedation in delta power and spindle activity. We tested the hypothesis that dex induces changes in the EEG that are similar to natural NREM sleep in young adult and old B6 mice.

[学科分类] 生理学