0140 Chemogenetic Activation of GABAergic and Glutamatergic Neurons in the Median Preoptic Nucleus Does Not Alter Isoflurane Anesthesia

[摘要] IntroductionAmple correlative evidence suggests that anesthetics act on neural networks that control sleep and wakefulness. The preoptic area of the hypothalamus is important for sleep generation and the regulation of sleep homeostasis, and a subset of GABAergic neurons in this area express cFos during the loss of consciousness caused by inhaled anesthetics. However, no studies to date have investigated a causal role for preoptic neurons in the regulation of the anesthetic state. This study tests the hypothesis that chemogenetic activation of GABAergic or glutamatergic neurons in the median preoptic nucleus (MnPO) influences anesthetic state transitions.

[学科分类] 生理学