0021 Lower Oxygen Saturation During Sleep Is Associated With Reduced Expressions Of Cd1d And Rab20 That Is Potentially Reversed By CPAP Therapy

[摘要] IntroductionObstructive Sleep Apnea (OSA) is associated with a wide range of physiological changes, many of which are secondary to overnight hypoxemia. Prior associations studies of OSA and gene expression in blood were performed in small, clinic based samples. Here we study OSA and hypoxemia-related gene expression associations in large population-based studies, and in a small sample of individuals with OSA before and after treatment using continuous positive airway pressure (CPAP) who participated in the Heart Biomarkers in Apnea Treatment Study (HeartBEAT).

[学科分类] 生理学