0009 Restless Leg Syndrome: Does It Start With A Gut Feeling?

[摘要] IntroductionEmerging research links gut microbial health with sleep. One common sleep disorder in which the microbiome may play a role is restless legs syndrome (RLS). While the pathogenesis of RLS is not fully understood, a relative state of brain iron deficiency has been described in patients with RLS and appears to induce changes in several pathways (adenosinergic, glutamatergic and dopaminergic) known to be involved in the disease. Insufficient iron may be secondary to dietary iron deficiency or, potentially, gut inflammation. We hypothesized that small intestinal bacterial overgrowth (SIBO), a condition associated with gut dysbiosis (i.e., normally rare gut-residing bacteria are over-represented in the gut), is associated with RLS and may moderate the observed inter-patient variability in serum iron availability.

[学科分类] 生理学