Dose-dependent effects of mandibular advancement on upper airway collapsibility and muscle function in obstructive sleep apnea

[摘要] Study ObjectivesMandibular advancement splints (MAS) are the leading treatment alternative to continuous positive airway pressure (CPAP) for obstructive sleep apnea (OSA). However, not all patients experience clinical benefit and treatment prediction remains challenging. Understanding the effects of mandibular advancement on pharyngeal collapsibility and muscle function may provide valuable information on the mechanisms of MAS, and thereby help to develop novel approaches for patient selection. Thus, we aimed to determine dose-dependent effects of mandibular advancement on pharyngeal collapsibility and muscle function concurrently in OSA patients undergoing MAS therapy.

[学科分类] 生理学

[关键词] sleep-disordered breathing;oral appliance therapy;upper airway physiology;phenotyping;endotyping;mechanisms