0056 SAMP8 Mice As A Preclinical Model For Irregular Sleep Wake Rhythm Disorder And Efficacy Of The Dual Orexin (Hypocretin) Receptor Antagonist Lemborexant

[摘要] IntroductionIrregular Sleep Wake Rhythm Disorder (ISWRD) is a common feature in Alzheimer’s disease (AD). Study objective was to identify a mouse model for ISWRD in AD responsive to treatment with an orexin receptor antagonist.

[学科分类] 生理学