0017 Multiple Types of Pathogen-Associated Molecular Patterns Activate Different Types of Inflammasomes Through Caspase-1 to Alter Sleep and Slow-wave Activity

[摘要] IntroductionInflammasomes are protein complexes that are activated by specific pathogen-associated molecular patterns (PAMPs) through corresponding pattern recognition receptors (PRRs) that stimulate caspase-1 to activate interleukin (IL)-beta (IL-1β) and IL-18 into their mature forms. Multiple inflammasomes exist that are activated by unique stimuli. The nucleotide-binding domain leucine-rich family pyrin containing 3 (NLRP3) inflammasome is activated by lipopolysaccharide (LPS) through toll-like receptor 4, NLRP1 is activated by muramyl dipeptide (MDP) through the nucleotide-binding oligomerization domain-containing protein-2 receptor, and retinoic acid-inducible gene-I (RIGI) is activated by double-stranded DNA including the synthetic deoxythymidylic acid sodium salt (poly dA:dT) through RIG-I-like receptors. NLRP3 inflammasomes are activated by sleep loss and LPS to enhance non-rapid eye movement (NREM) sleep and slow-wave activity (SWA). We determined if additional PAMPS and inflammasomes are involved in modulating sleep.

[学科分类] 生理学