0041 Preliminary Identification and Validation of a Plasma Metabolome-Based Biomarker for Circadian Phase in Humans

[摘要] IntroductionIdentifying a reliable predictor of circadian phase is increasingly important to diagnose circadian disorders and circadian misalignment, inform treatment schedules, and support personalized medicine. Findings using blood transcriptomics to predict circadian phase show promise, but no published findings have utilized a metabolomics approach. Therefore, the potential utility of metabolomics to predict circadian phase is unknown. Here, we analyzed the plasma metabolome during adequate and insufficient sleep to identify a circadian phase biomarker.

[学科分类] 生理学