0057 Sex-dependent Effects of Suvorexant on Sleep Fragmentation During Sleep Disruption Due to Noise Exposure.

[摘要] IntroductionSleep disruption (SD) contributes to obesity. Women are more likely to report insomnia and display greater sensitivity to SD-induced weight gain than men. Suvorexant is a dual orexin receptor antagonist that improves sleep. The compound also augments energy expenditure in rodents, and thus, may affect weight gain due to SD with potential sex differences. To begin to address this, we utilized a validated method of SD (i.e., environmental noise exposure) that causes weight gain in rats and determined whether suvorexant prevented noise-induced SD in male and female rats. We hypothesized that suvorexant would ameliorate noise-induced SD independent of sex.

[学科分类] 生理学