Reboxetine and hyoscine butylbromide improve upper airway function during nonrapid eye movement and suppress rapid eye movement sleep in healthy individuals

[摘要] Study ObjectivesRecent findings indicate that noradrenergic and antimuscarinic processes are crucial for sleep-related reductions in pharyngeal muscle activity. However, there are few human studies. Accordingly, this study aimed to determine if a combined noradrenergic and antimuscarinic intervention increases pharyngeal dilator muscle activity and improves airway function in sleeping humans.

[学科分类] 生理学

[关键词] obstructive sleep apnea;norepinephrine reuptake inhibitor;muscarinic antagonists;genioglossus;tensor palatini;upper airway physiology;sleep-disordered breathing