0025 Gene-based Analysis of Iron Related Pathways associated with Sleep-Disordered Breathing in Trans Omics in Precision Medicine (TOPMed)

[摘要] IntroductionAlthough OSA is heritable, few significant genetic associations have been observed in genome-wide association analyses largely because of limited power. Recent research suggest a novel role of iron metabolism in the pathophysiology of OSA, including metabolic and inflammatory pathways as well as ventilatory control mechanisms involving carotid body respiratory chemoreceptors. We aim to further study the underlying genetics linking iron metabolism pathways and OSA using deep sequencing data collected by NHLBI Trans-Omics for Precision Medicine (TOPMed) program.

[学科分类] 生理学