0065 Sleep and Wake Biomarkers of Psychotic Disorders and Their Relations with Thalamocortical Connectivity

[摘要] IntroductionRecent data implicate abnormalities of the thalamic reticular nucleus (TRN) and thalamocortical circuitry in schizophrenia (SZ) risk. Sleep spindles are initiated by the TRN and propagated to the cortex via thalamocortical feedback loops.During wakefulness, TRN modulates sensory processing by gating thalamocortical communication. Patients with SZ and their first-degree relatives (familial-high-risk,FHR) exhibit sleep spindle and sensory gating deficits. In two studies, we investigated the two SZ biomarkers in relation to thalamocortical connectivity in chronic and early-course psychotic disorders and FHR.

[学科分类] 生理学