0118 Increased Circulating Levels and Peripheral Tissue Promoter DNA Methylation of the Hormone FGF-21 Following Acute Sleep Loss in Humans

[摘要] IntroductionSleep loss and circadian misalignment alter energy metabolism in a tissue-specific manner. FGF-21 has tissue-specific and nutrient-dependent effects on metabolic substrate utilization, e.g. increasing insulin sensitivity of adipose tissue, yet its role has not been investigated in humans exposed to acute sleep loss. Increased levels of FGF-21 are also seen in metabolic disease such as type 2 diabetes and obesity.

[学科分类] 生理学