α-Synuclein aggregates in labial salivary glands of idiopathic rapid eye movement sleep behavior disorder

[摘要] Study ObjectivesTo assess whether biopsy of the labial minor salivary glands safely detects phosphorylated α-synuclein (pAS) deposits in idiopathic rapid eye movement sleep behavior disorder (IRBD), a condition that precedes the cardinal manifestations of synuclein disorders associated with Lewy-type pathology, namely, Parkinson’s disease (PD) and dementia with Lewy bodies (DLB).

[学科分类] 生理学

[关键词] α-synuclein;idiopathic rapid eye movement sleep behavior disorder;labial minor salivary glands;Parkinson’s disease;dementia with Lewy bodies