In-field assessment of sodium oxybate effect in pediatric type 1 narcolepsy: an actigraphic study

[摘要] Study ObjectivesSodium oxybate (SXB) is a GABAergic agent widely used as off-label treatment in pediatric type 1 narcolepsy (NT1). Here, we aimed at analyzing by wrist actigraphy the sleep/wake profile of NT1 children and adolescents in drug-naïve condition and after 1 year of SXB treatment. As secondary aim, we investigated changes on sleepiness, cataplexy, and children’s anthropometric profile after 1 year of SXB treatment.

[学科分类] 生理学

[关键词] type 1 narcolepsy;children;actigraphy;sodium oxybate;cataplexy;weight loss